Carnosine(100 grams) Retail: , Now only: $84.95
Carnosine(200grams) Retail: $225, Now only: $149.95

Key: Anti-aging, anti-wrinkles (anti-glycation), anti-inflammatory, athletic performance, chelating agent.

Targets: Neurological disease, atherosclerosis, wrinkled skin, diabetic complications.

Second Opinion: overwhelming consenus is very favorable. Discussion board members have wondered why the body has an enzyme carnosinase to de-activate carnosine, but research has shown no dangers or risks. In fact, human muscle has more carnosine than many other animals, suggesting it is more critical to us than even many animal based studies demonstrate.

Dose: at least 1,200 mg to overcome the de-activation of carnosinase. Preferred dose is 1,500 to 2,500 mg/day.

Carnosine(B-alanyl-L-histidine) is another of KiloHealth Top 10 supplements because of its powerful effects on the body. It is a naturally-occurring di-peptide (a combination of two amino acids), found in muscle, brain and other innervated animal and human tissues. It is formed by a process involving the enzyme carnosine-synthetase which bonds the amino acids alinine and histidine. This process occurs mainly in muscles and brain.
Carnosine has a number of interesting actions:
1. it is a potent antioxidant, it helps to chelate ionic metals (i.e. flush toxins from the body),
2. it has immune boosting properties (aids wound healing)
3. and is also known to reduce and prevent cell damage caused by beta amyloid (the substance found in the brain of Alzheimer disease patients). Carnosine helps protect neural tissues by blocking and inactivating beta amyloid and therefore it could help protect tissues against dementia
4. Carnosine's ability to help prevent glycation- the cross linking of proteins (and DNA molecules) caused by sugar aldehydes reacting with amino acids. This creates Advance Glycation End-products (AGE's). Such anti-glycation may be beneficial for diabetes, cataracts, neuropathy, kidney failure and skin conditions, as well as anti-aging properties.
5. In 1999, Australian researchers confirmed that carnosine increases longevity of human fibroblast cells in the laboratory. Carnosine extended the Hayflick limit (the maximum number of times a cell can divide), from a normal 50 by up to an additional 10 times! Although not enough time has passed to test these results, carnosine may be a supplement of choice for longevity.
6. a reduction of gastric ulceration (particularly when the ulcer is related to stress), both by preventing the formation of the ulcer and by healing it (carnosine increases the formation of granulation tissue). It does not affect acid secretion.
7. to lower blood pressure,
8. Carnosine gives a pronounced effect on primary senile cataracts, the effective rate being 100%. For mature senile cataracts, the effect rate is 80%, and positive effects were observed with other types of cataract. It is significant that no side effect has been found in the observed cases.
9. It is, however, striking that human muscle contains 20 mM carnosine, whereas mouse muscle contains only 1 mM. This suggests that carnosine may have a more fundamental role in cellular maintenance, since it is well established that the efficiency of maintenance in mammalian species is correlated with lifespan. The proposed maintenance function could include antioxidant activity, chelation of toxic metals, and the inhibition of non-enzymic glycosylation of proteins and the accumulation of AGEs (advanced glycation end products). These high-molecular-weight aggregates are seen in several tissues in senescent animals and obviously accumulate more rapidly in short-lived animals than in long-lived ones.